Leveraging decades of engineering leadership, our portfolio supports the world’s leading pharma, biotech, and CDMO companies in transitioning seamlessly from early-phase development to global GMP manufacturing.
Tailored Solutions for Diverse Molecular Profiles
Different molecules demand different physical environments. Sartorius provides specialized column technologies designed to optimize the performance of specific resin types and molecular structures.
1. Low-Pressure Liquid Chromatography (LPLC)
Designed for the gentle purification of large molecules, LPLC columns maintain bed integrity and protect sensitive biologics from shear stress.
Ideal for: mAbs, ADCs, Vaccines, and Blood/Plasma-derived products.
Resin Compatibility: Optimized for soft bead resins (e.g., agarose-based).
Systems: Resolute® AutoPak (fully automated) and Resolute® ManuPak/Prochrom (manual).
2. High-Pressure & Dynamic Axial Compression (DAC)
For processes requiring high-resolution separation of small molecules, our DAC columns offer unmatched bed stability and high-performance flow paths.
Ideal for: Insulin, GLP-1, Peptides, and Oligonucleotides.
Resin Compatibility: Engineered for hard bead resins (e.g., rigid polymer or silica-based).
Global Standard: Our DAC technology is a trusted fixture in virtually every insulin production plant worldwide.
Core Innovations & Technological Edge
Sartorius continues to redefine downstream processing through patented innovations that prioritize safety, speed, and reliability:
Pack-in-Place Nozzle Design: A revolutionary invention that allows for faster, safer, and more consistent column packing, minimizing downtime and human error.
Full Scalability: Our designs ensure linear performance from pilot-scale process development to full-scale commercial production, simplifying tech transfer.
Automated Precision: The Resolute® AutoPak system provides automated resin handling, ensuring reproducible packing results regardless of operator skill level.
Universal Compatibility: Our columns integrate seamlessly with leading chromatography skids, automated platforms, and all major resin brands.
Expert Support & Life-Cycle Management
Purification is not just about hardware; it is about process optimization. Sartorius provides a holistic support ecosystem to ensure your facility operates at peak performance:
Validation & Training: Comprehensive global services to assist with regulatory compliance and staff technical proficiency.
Process Optimization: Expert consultation to select the right column based on your molecule type, resin characteristics, and automation needs.
Maintenance & Longevity: Clear protocols for short-term and long-term storage and spare part management to extend column lifespan and ensure product quality.
