In the fast-evolving world of biopharmaceutical manufacturing, optimizing downstream processing is the key to unlocking higher productivity and reducing costs. The Resolute® BioSMB PD is an advanced, open-platform system engineered to convert traditional batch chromatography into a streamlined, continuous process without compromising performance or product quality.
Designed with precision engineering and patented technology, this system provides the ideal solution for companies focused on process development and clinical manufacturing.
What sets the Resolute® BioSMB PD apart is its nature as an open platform. This flexibility empowers users to apply virtually any separation technology that aligns with their process goals, including:
– Packed-bed Chromatography
– Membrane Chromatography
– Monoliths
– Expanded Bed Adsorption (EBA) Chromatography
This powerful system supports a wide range of standard use cases. Whether you are in the Capture phase using Protein A affinity chromatography, performing Bind/Elute tasks with Ion Exchange or Mixed-Mode resins, or conducting final Polishing steps with Size Exclusion or Ion Exchange membranes, the Resolute® BioSMB PD delivers unmatched consistency.
A major hurdle in continuous chromatography is the complexity of valve systems. The Resolute® BioSMB PD overcomes this with its patented valve cassette design. By organizing all system valves into a single, integrated cassette, this innovation:
– Makes single-use, multi-column chromatography viable and practical.
– Drastically reduces the risk of cross-contamination.
– Minimizes setup time and operational complexity.
– Primary Applications: mAB Production, Antibody Purification, Polishing, Capture, and Affinity chromatography for large molecules.
– Flow Rate Range: 1 – 100 mL/min
– Dimensions (W x D x H): 155 × 81 × 61 cm
– Operating Temperature: 4 – 40 °C
– Max Operating Pressure: 10 barg (145 psig)
– Power Requirements: 100–240 VAC, 50–60Hz (380W)
